Fine & Specialty Chemicals

ZEOflair high silica zeolites can be used as a highly active adsorbent for the removal of residual reactants or undesired by-products in chemical reactions.



The cosmetic industry makes use of a series of ingredients, including phospholipids, vitamins and squalene, that will demand a chromatographic separation and purification step in the manufacturing process.

Zeochem’s ZEOprep range of silica gels offers well-proofed stationary phases which are widely used in the industrial scale production of such materials. The broad variety of different silicas available, as well as batch sizes adapted to customers’ processes and demand, allow us to meet many kinds of requirements, whatever the target material may be. High yields, purity and reproducibility are as important as process safety and strict QA requirements, all of which are met when using ZEOprep silica gels.

Zeochem’s Research & Development departments in Switzerland and the U.S. have built decades of knowledge within topics such as:

  • NMR Spectroscopy
  • Isotopic Labeling
  • Molecular Sieves
  • Specialty Zeolites
  • Chromatography Gels

The knowledgeable and experienced members of our research and development team provide support in creating innovative, market-leading products. Team members are committed to supporting and optimizing manufacturing processes. Our team also offers in-house method development services for chromatographic purification applications.

Athletes and sports enthusiasts have driven apparel manufacturers to innovate their product lines since the 1980s. More recently, both groups have favored technologies that make them more comfortable in active-wear as this apparel has become more commonplace in today’s fashion. The technologies not only include more breathable and perspiration control technology but, thanks to ZEOflair type of adsorbents, also an effective body odor control. ZEOflair adsorbents can be incorporated into apparel manufacturing processes (both clothing and footwear) for true odor removal functionality, not odor masking. Given ZEOflair’s proven success in personal care formulations and VOC (volatile organic compound) abatement markets removing odor-causing compounds, it is not surprising body odor control through apparel delivery method has become more broadly accepted.

ZEOflair products offer the following advantages to sports apparel manufacturers:

  • Odor removal to virtually imperceptible levels due to its organophilic properties
  • High hydrophobic nature which helps retain its adsorption odor capacity in wet conditions (perspiration and apparel laundering)
  • Choice of ZEOflair products to truly target body odor types while meeting the needs of manufacturing demands

ZEOflair adsorbents can be used for body odor control in baby diapers, adult incontinence products, feminine hygiene (sanitary napkins), body wipes and other products that are not knitted or woven.

Incorporation of ZEOflair adsorbents during the nonwovens’ manufacturing process is a natural progression in today’s consumer market where odor removal or elimination is expected and demanded. As the elderly population grows around the world, the adult incontinence subcategory is predicted to increase. ZEOflair adsorbents offer the ability to physically remove urine, fecal and other body odors to imperceptible levels with virtually no potential of changing the odors as the result of chemical reaction by-products.

ZEOflair products offer the following advantages to makers of nonwovens:

  • Odor removal to virtually imperceptible levels due to its organophilic properties
  • High hydrophobic nature which helps retain its adsorption odor capacity in wet conditions
  • Choice of ZEOflair products to truly target the types of body odors while meeting the needs of the manufacturing demands

Food/beverage and pharmaceutical manufacturers demand sophisticated packaging that protects the integrity of their products through the various distribution channels. The products integrity (taste or odor) can be impacted by external VOCs and other permeable compou'nds the packaged goods are exposed to in the outside environment (e.g., fuel, detergents, printing inks, adhesives, etc.). Also, the products’ integrity can be impacted by the manufacturing processes of the packaging materials generating off-flavor/taste compounds. For example, the polymeric materials may undergo thermo-oxidative degradation, and there could be interaction with the other additives used in the polymers.

ZEOflair adsorbent powders can be incorporated into packaging at small concentration levels as additional protection for various food/beverage or pharmaceutical packaging material in single or multiple layers to provide a consistent food/beverage product taste/odor regardless of the packaging material’s sourcing and storage history.

For the purification of peptides, insulin (analogues) and oligonucleotides, it is often difficult to use methods similar to those applied in the purification of other organic compounds, mainly due to their complexity. Purification methods usually utilize various principles of chromatography such as ion exchange chromatography and medium or high-pressure reversed-phase chromatography.

Due to increasing government and public pressure to decrease costs of medicines, the purification process should be as simple as possible and contain a minimum of steps. However, the reality is that by using today's classical ion-exchange and/or reversed-phase purification methods, multiple steps are still required to achieve the desired purity. Of course, this has a huge impact on the recovery (yield). Besides this, more organic solvent must be used – all resulting in an inefficient, costly purification process.

ZEOsphere DRP Mixed-Mode materials can substantially improve the selectivity of charged molecules from the adsorption on the hydrophobic sites and repulsion on the charged sites.

This enhanced selectivity leads to desired purity more quickly and will considerably increase the recovery (yield). Because ZEOsphere DRP Mixed-Mode materials can work with low organic solvent conditions, a decrease in organic solvent usage is obtained.

ZEOsphere DRP Mixed-Mode products are today’s answer to improve compound purification and to considerably lower production costs.

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Custom Solutions

Zeochem's technical service team, engineers and chemists have decades of experience and are here to answer questions, troubleshoot and find solutions to your most challenging problems.

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ZEOflair 100/110

Highly active, hydrophobic adsorbent with high thermal stability for the removal of undesirable odors and flavors. ZEOflair 100/110 also effectively removes larger odor molecules.

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Highly active, hydrophobic/hydrophilic adsorbent for the removal of undesirable odors and flavors. ZEOflair 350/1000 also effectively removes larger odor molecules.

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Highly active, hydrophobic adsorbent with a high thermal stability for the removal of undesirable odors and flavors. It also effectively removes larger odor molecules, such as aromatics.

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ZEOprep 60 C18 / 40-63µm

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ZEOprep 60 C8 / 40–63µm

Alkyl-bonded silica with shorter chain length and slightly reduced hydrophobicity which is used in reversed-phase chromatography. The shorter alkyl length...

ZEOprep 60 CN / 40-63µm

Cyan-bonded silica is more polar than C18/8 bonding but is mostly used in reversed-phase chromatography for polar compounds and for...

ZEOprep 60 Diol / 40-63µm

Diol-bonded silica, more polar than C18/C8 types. Used in reversed- as well as in normal-phase chromatography, it is the product...

ZEOprep 60 NH2 / 40-63µm

Amine-bonded silica is mostly used in normal-phase chromatography and serves as an efficient metal scavenger in batch applications, best for...

ZEOprep 60 NH2P / 40–63µm

Primary, secondary amine-bonded silica and is more polar than C18/C8 phases. It is used in reversed-phase as well in normal-phase...

ZEOprep 60 SAX / 40-63µm

Silica-bonded for anion exchange chromatography.

ZEOprep 60 SH / 40-63µm

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ZEOprep 90 C18 / 40-63µm

Alkyl-bonded silica with 90 angstrom pore size that has proved to be a robust packing material in particular for flash...

ZEOprep 90 C18 / 60-200µm

Alkyl-bonded silica with 90 angstrom pore size and a larger particle size distribution which provides a higher flow rate under...

ZEOprep 90 C8 / 40-63µm

Alkyl-bonded silica with 90 angstrom pore size with shorter alkyl chain length and slightly reduced hydrophobicity. It is used in...

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Cyan-bonded silica with 90 angstrom pore size, more polar than C18/8 bonding but mostly used in reversed-phase chromatography for polar...

ZEOprep 90 NH2 / 40-63µm

Amine-bonded silica with 90 angstrom pore size, mostly used in normal phase chromatography. It serves as an efficient metal scavenger...

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Frequently Asked Questions

  • The larger the molecular weight of the target molecule to be separated the larger the pore size needs to be. The sample molecules need to be able to interact with the pores of the particle to create an efficient separation mechanism. If the pores are smaller than your target molecule it will not be retained and elute immediately.
  • The larger the average pore size of the material the smaller will be the effective surface area. If you have less surface area available, your separation is generally less efficient. It is important to choose the right pore size for your target molecule.
  • Size and distribution of the silica particles effect the packing efficiency of the columns and therefore process performance.
  • The higher the packing density, the higher the surface area, the more interaction between eluent and separation material resulting in higher efficiency separation. However, the higher the packing density, the smaller the mean particle size is and therefore the higher the backpressure will be.

Bonding different chemical groups onto the surface of bare silica results in functionalized silicas which give higherselectivity towards specific molecules.

  • Bare/Silica has a high polar surface, it is the most popular stationary phase, ideal for conventional applications (normal phase separations, non-polar target molecules, pharmaceuticals, natural products)
  • C4; suited to molecules with large hydrophobic regions, peptides, proteins. Usually combined with a large pore size for big biomolecules (>1000Da)
  • PHE/phenyl; moderately nonpolar for aromatic compounds, aflatoxins, caffeine, phenols.
  • C8; highly hydrophobic pesticides, peptides, drugs
  • C18; more apolar than C8 and in reversed phase chromatography higher retention than C8. Has a non-polar surface, ideal for pharmaceuticals, steroids, fatty acids, peptides, proteins, pesticides, PCB’s
  • Amino/NH2has a medium polar surface, ideal for carbohydrates and nitrogen containing heterocycles and amines. Scavenger applications.
  • Diolhas a lesspolar surface (than bare silica) and still many hydroxy-groups, ideal for lipids; Our best option for many SFC applications.
  • Cyano/CN unique selectivity for polar analytes with widely different chemistry eg. Cyclosporine, carbohydrates
  • Thiol/SH; Mainly used for scavenging
  • SCX/SO4:Ion Exchange for strong cation
  • SAX/TMA; Ion exchange for weak anion
  • NH2P; Ion exchange for scavenging

Yes, they are.

Excellent ZEOflair powder dispersion in the formula, choosing the correct ZEOflair powder type, and achieving the correct additivation (concentration) levels.

  • Morphology of the silica particles; meaning bead shape
  • Surface area: this is a function of particle- and pore size
  • Surface functionalisation
  • Particle size distribution in terms of range and actual distribution of particles within the range (D10/D50/D90)
  • Irregular silica beads to be used in low -medium pressure systems
  • Spheroidal Silica beads can be used in low to high pressure systems
  • Spherical silica beads primarily used for high-resolution high-pressure systems

it depends on the size & concentration levels of odor/VOC compounds one tries to target for removal in the formulation. Type 100/110 for smaller size compounds, type 350 for medium size compounds, and type 800/810 for larger size compounds.

ZEOflair powders’ ability to remove odor/VOC compounds at elevated temperatures is diminished. However, as the material starts to cool down, the odor/VOC compounds that are still left in the formulation will be adsorbed by ZEOflair powders